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VESPER-1: the durability signal In a 32-week exploratory extension (Part B) of VESPER-1, Pfizer reports a 15.9% non-placebo-adjusted weight loss with no plateau observed at 32 weeks on 2.4 mg weekly berobenatide in participants who escalated from placebo to active drug

Not equivalent to physiologic restoration Increasing GH secretion does not necessarily restore normal timing, tissue specificity, or feedback regulation

Integrating the scoping review with insights derived from the NGT facilitates gathering real-world clinical insights

Some products claim to support the body's natural GLP-1 response, but these claims are not the same as proving a medical effect

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